經(jing)過(guo)研究(jiu)證實培(pei)養基變異(yi)會(hui)影響到(dao)不(bu)同人(ren)對疼(teng)痛(tong)的感受

經(jing)過(guo)研究(jiu)證實培(pei)養基變異(yi)會(hui)影響到(dao)不(bu)同人(ren)對疼(teng)痛(tong)的感受

　　培(pei)養基介紹(shao)，P2RX7基因的(de)遺(yi)傳(chuan)性變(bian)異(yi)會(hui)影響到(dao)不(bu)同人(ren)對疼(teng)痛(tong)的感受。因為(wei)疼(teng)痛(tong)感知的(de)個(ge)體差(cha)異(yi)性和(he)對(dui)疼(teng)痛(tong)緩(huan)解(jie)藥(yao)物(wu)的(de)反(fan)應不(bu)同，疼(teng)痛(tong)相關臨(lin)床試(shi)驗的(de)進(jin)行(xing)壹直(zhi)都存在壹定難(nan)度(du)，這(zhe)項研(yan)究(jiu)或(huo)能有助我們在該(gai)基因變(bian)異的基礎上(shang)開發出(chu)相應的個(ge)體疼(teng)痛(tong)療(liao)法(fa)。

　　培(pei)養基指出(chu)，Jeff Mogil、Michael Salter等人(ren)觀察了(le)大(da)量小鼠的(de)不(bu)同疼(teng)痛(tong)敏(min)感度(du)，註意(yi)到小鼠P2RX7基因的(de)突變與這(zhe)些(xie)差(cha)異(yi)有關。他(ta)們發現該(gai)基因的(de)某(mou)壹變(bian)異(yi)讓(rang)壹種(zhong)具(ju)有細(xi)胞(bao)膜中(zhong)離(li)子通道作(zuo)用(yong)的受(shou)體P2X7生成大(da)孔(kong)徑(jing)；產生該(gai)基因變(bian)異的小鼠比(bi)未(wei)產生變(bian)異的(de)小鼠會(hui)表現(xian)出(chu)更(geng)多疼(teng)痛(tong)，而壹種(zhong)能阻礙該(gai)大(da)孔(kong)徑(jing)生(sheng)成(cheng)的(de)縮氨(an)酸(suan)則(ze)可(ke)以減(jian)輕變異(yi)小鼠的(de)疼(teng)痛(tong)。之後(hou)，Salter和同事將該(gai)發(fa)現應用(yong)於人(ren)體試(shi)驗，他(ta)們發現如(ru)果P2RX7基因的(de)變異不(bu)導(dao)致(zhi)P2X7受(shou)體生成大(da)孔(kong)徑(jing)的(de)話(hua)，那(na)麽(me)乳(ru)房(fang)切(qie)除術後(hou)疼(teng)痛(tong)和關節(jie)炎(yan)疼(teng)痛(tong)的患(huan)者(zhe)會(hui)表現出(chu)較少的(de)疼(teng)痛(tong)。

N,N-二(er)乙基乙酰(xian)胺(an) Hexamethyleneimine 異(yi)丁酸(suan)苯(ben)氧乙(yi)酯(zhi) 90035
N,N'-二(er)乙基脲 -50-2 2-Phenoxyethyl isobutyrate 90033
N,N-二(er)乙基鄰甲苯(ben)胺(an) 己二(er)酰(xian)氯 03-6-7 90032
N,N-二(er)乙基-2,3,3,3-四氟(fu)丙(bing)酰(xian)... Adipoyl chloride 丁酸(suan)桂(gui)酯 90030
N,N-二(er)甲基鄰甲苯(ben)胺(an) -5-3 Cinnamyl butyrate 90029
N,N-二(er)芐(bian)基羥胺(an) N,N,N',N'-四(si)甲基-,4-丁二(er)胺(an) 03-63-9 9002
N,N'-二(er)苯基聯苯胺(an) N,N,N',N'-Tetramethyl-,4-butanediamine β-溴(xiu)苯乙烷 90020
N,N-二(er)苯基甲酰(xian)胺(an) -55-7 (2-Bromoethyl)benzene 9002
N,N-二(er)苯基對苯(ben)二(er)胺(an) 乙(yi)二(er)醇二(er)醋酸(suan)酯(zhi) 03-64-0 9000
N,N-二(er)(2-吡(bi)啶(ding)甲(jia)基)炔丙(bing)氨(an) Ethylene glycol diacetate β-溴(xiu)苯乙烯 90009
N,N'-dipropylurea -58-0 Beta-Bromostyrene, mixture of cis/trans isomers 90008
N,N-diphenylformamide 油酰(xian)乙(yi)醇胺(an) 03-65- 90007
N,N'-Diphenylethanediamide N-oleoyl ethanolamine 丙(bing)苯 7270
N,N'-Diphenylbenzidine -6-5 n-propylbenzene 7269
N,N-Dimethyl-o-toluidine 硬(ying)脂酸(suan)乙(yi)酯 03-67-3 7268
N,N'-dimethyl-N,N'-bis(3-methylaminopropyl)trimethylenediami... Ethyl stearate 甲(jia)基芐(bian)胺(an) 7267
N,N'-Diisopropylcarbodiimide -62-6 N-Methylbenzylamine 7256
N,N-diethyl-o-toluidine 油(you)酸(suan)乙(yi)酯 03-69-5 7255
N,N-Diethylacetamide Ethyl Oleate N-乙(yi)基苯胺(an) 7254
N,N-diethyl-2,3,3,3-tetrafluoropropionamide -63-7 N-Ethylaniline 7249
N,N-Dibenzylhydroxylamine 硬(ying)脂酸(suan)乙(yi)烯酯 03-70-8 7246
N,N-Bis(2-Pyridylmethyl)-N-Propargylamine Vinyl stearate N-甲酰(xian)苯(ben)胺(an) 7244
N,N',N''-*基二(er)丙(bing)撐三胺(an) -64-8 Formanilide 724
N,N',N'',N'''-四(si)甲基三丙(bing)撐四... 辛酰(xian)氯 03-7-9 7237
N-(N-glycylglycyl)glycine Octanoyl chloride 7236
N-(Hydroxymethyl)phthalimide -65-9 Phenyl isocyanate 7235
N-(HYDROXY)PHTHALIMIDE 辛烷 03-72-0 7234
N-(5-溴(xiu)喹(kui)喔(wo)啉(lin)-6-基)硫脲 n-Octane 異硫氰酸(suan)苯(ben)酯 7233
N-(5-amino-9,0-dihydro-9,0-dioxo--anthryl)benzamide -66-0 Phenyl isothiocyanate 7228
N-(4-氯-3-氰基-7-乙氧(yang)基喹(kui)啉(lin)-... -辛烯 03-73- 7227
N-(4-聯苯基)-N-(4-溴(xiu)苯基)-(9... -Octene 苯 7224
N-(4-氟(fu)苯(ben)基)--甲基-H-咪唑(zuo)-... -68-2 phenetole 724
N-(4-Fluorophenyl)-methyl-H-imidazole-4-carboximidamide 庚(geng)胺(an) 03-74-2 7209
N-(4-Chlorophenyl)-methyl-H-imidazole-4-carboximidamide n-Heptylamine 2-乙(yi)醇吡(bi)啶(ding) 7208
N-(4-Chloro-3-cyano-7-ethoxy-6-quinolinyl)acetamide -69-3 2-(2-Hydroxyethyl)pyridine 50602
N-(4-bromo-5-methyl-6-nitrophenyl)acetamide 己二(er)腈 03-75-3 5060
N-(4-biphenyl)-(9,9-dimethylfluoren-2-yl)Amine ,4-Dicyanobutane 2-乙(yi)氧基-3,4-二(er)氫(qing)吡(bi)喃 50600