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產(chan)品(pin)屬(shu)性(xing):
產(chan)品(pin)名稱 | 規(gui)格(ge) | 貨(huo)號(hao) |
NCT-501 (hydrochloride) | 1mg、5mg、10mg、25mg | GOY-01Y65610 |
產(chan)品(pin)名稱:NCT-501 (hydrochloride)
規(gui)格(ge) :1mg、5mg、10mg、25mg
Cas No.: N/A
別(bie)名: N/A
化(hua)學(xue)名: N/A
分(fen)子(zi)式(shi): *•HCl

分(fen)子(zi)量(liang): 453
溶(rong)解(jie)度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 10 mg/ml
儲(chu)存(cun)條件: Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chan)品(pin)描述:
Aldehyde dehydrogenases (ALDHs) catalyze the NAD(P)+-dependent oxidation of aldehyde-containing substrates to the corresponding carboxylic acids. ALDH1A1 activity is elevated in certain stem cells and cancers. NCT-501 is a potent, reversible, theophylline-based inhibitor of ALDH1A1 (IC50 = 40 nM for the human form). It is selective for ALDH1A1 over other ALDH isozymes as well as other dehydrogenases. Pharmacokinetic studies indicate that NCT-501 has high bioavailability when delivered intraperitoneally, with rapid phase I modification in the liver.
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