針對兒童時期病(bing)毒(du)研(yan)究出(chu)更(geng)好(hao)的(de)疫苗
據(ju)壹項新的(de)研(yan)究報(bao)告,ELISA試(shi)劑(ji)盒多(duo)虧了(le)壹些分子工程(cheng)的(de)研(yan)究,在zui後壹批(pi)還(hai)沒有(you)獲(huo)得經批準可(ke)使用(yong)的(de)疫苗的(de)兒(er)童疾病(bing)之(zhi)中,有(you)壹種(zhong)疾病(bing)可(ke)能(neng)在不(bu)久之(zhi)後就(jiu)會有(you)疫苗了(le)。呼(hu)吸道(dao)合胞(bao)病(bing)毒(du)或(huo) RSV 可通過(guo)學校或(huo)日托(tuo)中心而(er)引起傳播(bo)速(su)度很快的(de)傳染性(xing)*的(de)肺部(bu)感染(ran)。它是(shi)5歲(sui)以(yi)下兒(er)童(tong)住院的(de)zui常(chang)見的(de)原因,但(dan)是(shi)研(yan)究人(ren)員卻壹直(zhi)無(wu)法(fa)設計壹種(zhong)針對它的(de)有(you)效(xiao)疫苗。
在這項研究中,Jason S. McLellan 及(ji)其(qi)同(tong)事(shi)基(ji)於(yu)先(xian)前的(de)研(yan)究顯(xian)示(shi),ELISA試(shi)劑(ji)盒壹種(zhong)在 RSV 膜中的(de)叫做F蛋(dan)白的(de)蛋(dan)白質(zhi)會在其(qi)融(rong)合前狀態(tai)(當其(qi)位(wei)於(yu)病(bing)毒(du)表(biao)面(mian)時所采(cai)取的(de)狀(zhuang)態)但卻不(bu)會在其(qi)融(rong)合後狀態(tai)(在侵入(ru)細胞(bao)後所采(cai)取的(de)狀(zhuang)態)成為抗(kang)體(ti)的(de)標(biao)靶。
ELISA試(shi)劑(ji)盒研究人(ren)員對該蛋(dan)白融(rong)合前結構(gou)上的(de)某(mou)壹特(te)別位置(zhi)進行了操(cao)控(kong)——他們用(yong)這壹技(ji)術設計了 00 多(duo)個變(bian)異株——並接著(zhe)在小鼠(shu)及恒(heng)河(he)猴中對6種穩定的(de)變(bian)異株進行了測試(shi)。他們將這(zhe)些動物(wu)進行免疫以(yi)觀(guan)察(cha)哪(na)些F蛋(dan)白變(bian)異株(起著(zhe)抗原的(de)作(zuo)用(yong))會產生(sheng)*的(de)保護(hu)性(xing)反應(ying)。ELISA試(shi)劑(ji)盒特別當用(yong)某(mou)壹融(rong)合前結構(gou)進行免疫時能導致比用(yong)融合(he)後糖蛋(dan)白進行免疫時要多(duo)出高(gao)達0倍(bei)的(de)抗(kang)體(ti);融(rong)合後糖蛋(dan)白目(mu)前是(shi)主(zhu)要的(de)現在正(zheng)在進行臨(lin)床試(shi)驗(yan)的(de)RSV候選(xuan)疫苗的(de)壹部(bu)分。
LHRH(Mouse Luteinizing Hormone-Releasing Hormone) ELISA Kit 小鼠黃體(ti)生(sheng)成素(su)釋放激(ji)素(su) Multi-class antibodies 規(gui)格(ge): 48T
NGB(Mouse Neuroglobin) ELISA Kit 小鼠腦紅(hong)蛋(dan)白 Multi-class antibodies 規(gui)格(ge): 48T
8-iso-PG(Mouse 8-iso prostaglandin) ELISA Kit 小鼠8異(yi)前列腺(xian)素(su) Multi-class antibodies 規(gui)格(ge): 48T
IFI6/p6(Mouse interferon-inducible protein 6) ELISA Kit 小鼠γ幹擾素(su)誘(you)導(dao)蛋(dan)白6/p6 Multi-class antibodies 規(gui)格(ge): 48T
SDF-a/CXCL2(Mouse Stromal cell derived factor a) ELISA Kit 小鼠基(ji)質(zhi)細胞(bao)衍生(sheng)因(yin)子(zi)a Multi-class antibodies 規(gui)格(ge): 48T
VEGF(Mouse Vascular Endothelial cell Growth Factor) ELISA Kit 小鼠血管內皮(pi)細胞(bao)生(sheng)長因子(zi) Multi-class antibodies 規格(ge): 48T
GMP-40(Mouse alpha-granular membrane protein) ELISA Kit 小鼠血漿α顆(ke)粒膜蛋(dan)白 Multi-class antibodies 規(gui)格(ge): 48T
MPO(Mouse myeloperoxidase) ELISA Kit 小鼠髓(sui)過(guo)氧(yang)化物(wu)酶(mei) Multi-class antibodies 規(gui)格(ge): 48T
Gzms-B(Mouse granzymes B) ELISA Kit 小鼠顆(ke)粒酶(mei)B Multi-class antibodies 規(gui)格(ge): 48T
VEGFR-/Flt(Mouse Vascuoar endothelial cell growth factor receptor ) ELISA Kit 小鼠血管內皮(pi)細胞(bao)生(sheng)長因子(zi)受(shou)體(ti) Multi-class antibodies 規(gui)格(ge): 48T
Gzms-A(Mouse granzymes A) ELISA Kit 小鼠顆(ke)粒酶(mei)A Multi-class antibodies 規(gui)格(ge): 48T
Lptn/LTN/XCL(Mouse lymphotactin) ELISA Kit 小鼠淋(lin)巴(ba)細胞(bao)趨(qu)化因(yin)子(zi) Multi-class antibodies 規格(ge): 48T
VEGFR-2/Flk-(Mouse Vascuoar endothelial cell growth factor receptor 2) ELISA Kit 小鼠血管內皮(pi)細胞(bao)生(sheng)長因子(zi)受(shou)體(ti)2 Multi-class antibodies 規(gui)格(ge): 48T
TCC C5b-9(Mouse terminal complement complex C5b-9) ELISA Kit 小鼠末(mo)端(duan)補(bu)體(ti)復(fu)合物(wu)C5b-9 Multi-class antibodies 規格(ge): 48T
VEGFR-3/Flt-4(Mouse Vascuoar endothelial cell growth factor receptor) ELISA Kit 小鼠血管內皮(pi)細胞(bao)生(sheng)長因子(zi)受(shou)體(ti)-3 Multi-class antibodies 規(gui)格(ge): 48T
C4(Mouse Complement 4) ELISA Kit 小鼠補(bu)體(ti)蛋(dan)白4 Multi-class antibodies 規(gui)格(ge): 48T
Renin(Mouse Renin) ELISA Kit 小鼠腎(shen)素(su) Multi-class antibodies 規(gui)格(ge): 48T
Alpha2-AP(Mouse Alpha2-Antiplasmin) ELISA Kit 小鼠α2抗(kang)纖(xian)溶酶(mei) Multi-class antibodies 規(gui)格(ge): 48T
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